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Updated: Sep 10, 2025

Monitoring Dynamic Changes In Mitochondrial Calcium Levels During Apoptosis Using A Genetically Encoded Calcium Sensor
06:26

Monitoring Dynamic Changes In Mitochondrial Calcium Levels During Apoptosis Using A Genetically Encoded Calcium Sensor

Published on: April 1, 2011

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mTORC2/Akt軸は,セラストロール誘発のパラプトーシス中にタンパク質毒性ストレスとミトコンドリアのCa2+過剰負荷を促進する

Yeon Jung Park1, Mi-Young Cho2, In Young Kim3

  • 1Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, 16499, Republic of Korea.

Biochemical and biophysical research communications
|August 20, 2025
PubMed
まとめ

セラストロールは,非アポプトシス経路であるパラプトーシス経由で癌細胞死を誘発する. このプロセスは,タンパク質毒性およびミトコンドリアストレスを管理するmTORC2/Akt信号軸に依存しています.

キーワード:
アクトセラストロールミトコンドリアのCa2+) 過剰負荷パラプトーシスタンパク質毒性ストレスmTORC2 について

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