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Updated: Sep 10, 2025
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5歳児の骨のミネラル密度は,早産児と早産児の比較です
A M le Clercq1, D J Dorrepaal2, G F Hasperhoven1
1Department of Neonatal and Pediatric Intensive Care, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, the Netherlands.
Clinical nutrition (Edinburgh, Scotland)
|August 20, 2025
まとめ
非常に早産児 (VPB) は5歳の時に骨のミネラル密度 (BMD) が低下したが,この差は体積を考慮すると消えた. これは,骨の鉱化の問題ではなく, 骨密度の違いがVPB生存者を説明することを示唆しています.
科学分野:
- 小児科
- 新生児科
- 骨格の発達
背景:
- 非常に早産 (妊娠32週間未満) は,子宮外骨の鉱化が低下したため,骨格の発達障害に関連しています.
- 新生児集中治療室 (NICU) の栄養プロトコルは,VPBの乳児の骨密度 (BMD) をサポートすることを目的としています.
研究 の 目的:
- NICUの栄養プロトコルがVPBの子供におけるBMDを適切にサポートするかどうかを評価する.
- 5歳までのVPB児と,満期児のBMDを比較する.
主な方法:
- 94人のVPB児と259人の満期児を比較した前向きなコホート研究.
- ダブルエネルギーX線吸収測定法 (DXA) で,5歳の時,全身マイナス頭部 (TBLH) BMDを測定した.
- 標準偏差スコア (SDS) と複数の回帰分析を使用して,BMDを比較し,関連する要因を特定しました.
主要な成果:
- VPBの子どもは5歳の時,平均身長,体重,脂肪量,および痩身量SDSが低かった.
- VPBの子どもは,BMDTBLHが著しく低く,BMDの低い罹患率は,満期児と比較して高かった.
- 体サイズを調整したところ,VPBと満期児のBMDTBLHの違いはもはや有意ではなかった.
結論:
- VPBの子どもは5歳の時にBMDTBLHが低かったが,正常な範囲内だった.
- 低身長と痩身体重のSDSは,VPBの子供たちの観察されたBMDの違いを説明しました.
- 発見は,異常な骨の鉱化ではなく,変化した成長が,VPB生存者の骨密度の変動の根底にあることを示唆しています.
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