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関連する概念動画

Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.6K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Diffusion01:12

Diffusion

198.9K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
198.9K
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

433
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
433
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

932
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
932
Phase Transitions: Vaporization and Condensation02:39

Phase Transitions: Vaporization and Condensation

18.4K
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase...
18.4K
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

717
Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
717

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関連する実験動画

Updated: Sep 10, 2025

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
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From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope

Published on: October 9, 2014

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2相流体におけるインターフェーズ拡散:局所動態と有限サイズ効果

Quang K Loi1, Debra J Searles2

  • 1Centre for Theoretical and Computational Molecular Science, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.

Journal of colloid and interface science
|August 20, 2025
PubMed
まとめ
この要約は機械生成です。

有限サイズの効果は,インターフェースでの流体拡散に大きく影響します. 分子ダイナミクスのシミュレーションでは,ナノ限られた液体を真似して,インターフェースの性質とシステムのサイズに影響される拡散の局所的な変化が明らかになります.

キーワード:
限られたサイズインターフェース地元の拡散フェーズ分離

さらに関連する動画

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
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Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

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The Diffusion of Passive Tracers in Laminar Shear Flow
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The Diffusion of Passive Tracers in Laminar Shear Flow

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関連する実験動画

Last Updated: Sep 10, 2025

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
15:10

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope

Published on: October 9, 2014

11.5K
Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells
05:56

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

Published on: November 12, 2020

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The Diffusion of Passive Tracers in Laminar Shear Flow
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The Diffusion of Passive Tracers in Laminar Shear Flow

Published on: May 1, 2018

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科学分野:

  • 物理化学
  • 計算式流体力学

背景:

  • 流体-流体インターフェースの間の拡散は,工業分離および生物学的プロセスにおいて極めて重要です.
  • 局所的なインターフェースの構造は,拡散のダイナミクスを強く影響する.
  • これらのシステムをシミュレートすると,インタフェースの閉じ込めにより,有意な有限サイズの効果を発揮する可能性があります.

研究 の 目的:

  • 流体対流体界面におけるグローバルとローカルな拡散ダイナミクスを調査する.
  • 混合不可能な状態とシステムの大きさによる拡散の影響を決定する.
  • このようなシステムにおける有限サイズ効果の性質を明らかにする.

主な方法:

  • 分子ダイナミクスのシミュレーションが採用された.
  • レナード・ジョーンズ流体の二元混合物が研究されました.
  • 異なる程度の不混合性とシステムのサイズがシミュレートされました.

主要な成果:

  • 正常および横向的な拡散の強い局所的変動が観察されました.
  • 横向の拡散はインターフェイスでピークに達し,正常の拡散は不利な段階で最高でした.
  • 拡散に対する限られたサイズの効果は,ナノ限られた液体との類似性を示した.
  • 水力学的効果は 細胞の大きさの人工物で 横向の拡散に影響を与えます

結論:

  • 有限サイズの効果は,流体-流体界面での拡散ダイナミクスを著しく変化させる.
  • 種分布と水力学的な人工物は両方ともこれらの効果に寄与します.
  • 発見は,閉じ込められたシステムとインターフェースシステムの拡散に関する洞察を提供します.