関連する実験動画

Updated: Sep 10, 2025

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
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Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

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パーキンソン病に対する iPSC ベースのアロジェニック細胞治療の臨床試験における免疫応答の制御

Asuka Morizane1, Emi Yamasaki2, Takero Shindo3

  • 1Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan; Center for Clinical Research and Innovation, Kobe City Medical Center General Hospital, Kobe 650-0047, Hyogo, Japan.

Cell stem cell
|August 20, 2025
PubMed
まとめ

中枢神経系 (CNS) の誘導性多能幹細胞 (iPSCs) を用いたパーキンソン病の細胞治療は,より少ない免疫抑制を必要とします. iPSC由来細胞の低ヒト白血球抗原 (HLA) 発現は,免疫特権を持つ中枢神経への成功移植を助長する.

キーワード:
パーキンソン病細胞療法臨床試験植え付けヒト白血球抗原免疫拒絶症誘導された多能幹細胞ポジトロン放出トモグラフィー移植

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