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Updated: Sep 10, 2025

A Rapid In Vivo Bioassay for Developmentally Active Enhancers
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OTX2によるエンハンサー再構成は,哺乳類の最終的な内皮の仕様とパターンを指示する

Ly-Sha Ee1, Daniel Medina-Cano2, Emily Goetzler1

  • 1Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.

Developmental cell
|August 20, 2025
PubMed
まとめ

転写因子Otx2は哺乳類の胚の発達に不可欠であり,最終的な内皮と前腸の形成を調節する. その枯渇はWNT信号伝達,細胞粘着,そして系統の仕様を妨げます.

キーワード:
H3K27acOTX2 について前から後へ究極の内皮強化剤前腸ガストルレーション細菌層の仕様パターン付け転写因子

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