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関連する概念動画

Skin Cancer01:30

Skin Cancer

4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

2.6K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.6K
Mutations01:35

Mutations

39.9K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
39.9K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.1K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

12.7K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.7K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Updated: Sep 10, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

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皮膚 がん

Jonathon Firnhaber1

  • 1Department of Family Medicine, Brody School of Medicine, East Carolina University, 101 Heart Drive, Greenville, NC 27834, USA.

Primary care
|August 20, 2025
PubMed
まとめ
この要約は機械生成です。

基礎細胞癌および状細胞癌を含む非メラノーマの皮膚癌は一般的です. メラノーマは 深刻で増殖する皮膚癌で 異常な病変は 高い臨床的疑念を正当化します

キーワード:
アクティニクケラトーシス基礎細胞がん皮膚メラノーマケラトアカントーマ非メラノーマ皮膚がん状細胞がん

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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関連する実験動画

Last Updated: Sep 10, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

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A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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科学分野:

  • 皮膚科
  • 腫瘍学

背景:

  • ケラチノサイトがん (非メラノーマ性皮膚がん) は,ヒトで最も一般的な悪性腫瘍である.
  • 基礎細胞癌 (BCC) と皮膚状細胞癌 (cSCC) を含む.
  • 皮膚メラノーマの発生率は 世界的に増加しており,深刻な健康問題となっています.

研究 の 目的:

  • ケラチノサイト癌の一般的な臨床表現を記述する.
  • 皮膚メラノーマの深刻さと 増加傾向を強調するためです
  • メラノーマの検出における 臨床的疑惑の重要性を強調するためです

主な方法:

  • 一般的な皮膚がんの臨床的特徴に関する記述的レビュー
  • BCC,cSCC,およびメラノーマの視覚的診断シグナルに重点を置く.

主要な成果:

  • BCCは通常,目に見える血管を持つ真珠状のドーム状のパプルで表れます.
  • cSCCは通常,固い,多角性パプルまたはプラークとして現れ,時には潰瘍です.
  • メラノーマは,その変異的な外観と増加する流行により,高い臨床的疑念を必要とします.

結論:

  • 皮膚がんのサブタイプを早期に認識することは,適切な治療に不可欠です.
  • 臨床医はメラノーマを 高い確率で疑う必要があります 特に非典型的病変の場合です
  • BCC,cSCC,およびメラノーマの異なるプレゼンテーションを理解することは,診断に役立ちます.