関連する実験動画

Updated: Sep 10, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
08:04

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

19.1K

アミノ酸によるmTORC1の動的調節のための構造的基礎

Max L Valenstein1,2,3,4, Maximilian Wranik5,6,7, Pranav V Lalgudi2,3

  • 1Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Nature
|August 20, 2025
PubMed
まとめ

成長に不可欠なラパミシン複合体1 (mTORC1) 経路のメカニズム的標的は,栄養センサーによって調節されます. この研究では,アミノ酸センサーSestrin2とCASTOR1がGATOR2複合体と結合し,mTORC1の活性化を制御する方法を明らかにしました.

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Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

261
A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation09:37

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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