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Updated: Sep 10, 2025

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
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マウスのcIAP1/2によるTNFシグナル伝達経路のダウンレギュレーションにより,Corynebacterium glutamicumが大腸炎を緩和した

Ting Liu1, Qiang Meng1, Yijun Zhang1

  • 1College of Food Science and Technology, Northwest University, Xi'an, Shaanxi, 710069, China. mengqiang@nwu.edu.cn.

Food & function
|August 21, 2025
PubMed
まとめ

炎症を軽減し,腸内微生物のバランスを回復することによって,HA-SH水凝土にカプセル化されたコリーネバクテリウムグルタミカムは,潰瘍性大腸炎 (UC) を効果的に治療します. このプロバイオティクスの治療は,TNFとNF- kBの信号伝達経路を標的とし,治療上の利益をもたらします.

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
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