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Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
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抗酸化物質:胎児の低酸素と闘う力
Kimberley J Botting-Lawford1, Katie L Skeffington2, Michael P Murphy3
1EGA Institute for Women's Health, University College London, London, UK.
まとめ
抗酸化物質は胎児の低酸素による心血管のリスクを防ぐことができますが,胎児の脳を節約する反応を保たなければなりません. ミトコンドリアを標的にする抗酸化物質MitoQは,この二重の利点について,臨床前試験で有望であることが示されています.
科学分野:
- 産前医学
- 心血管生物学
- 発達生理学
背景:
- 胎児の低酸素は,分娩中に急激に発生するか,様々な状態のために慢性的に発生するので,子宮の心臓血管の健康にリスクがあります.
- 慢性的な低酸素は酸化ストレスを誘発し,成人の高血圧と冠動脈疾患に子孫を誘発します.
- 胎児の脳を保存する反応は 急性低酸素症への重要な適応であり 重要な臓器の酸素供給を優先します
研究 の 目的:
- 低酸素妊娠の子どもの心血管疾患の予防における抗酸化効果に関する臨床前研究の検証.
- プログラムされた心血管疾患と胎児の脳への抗酸化効果を比較する
- 予防と胎児防衛のバランスをとる 臨床翻訳に適した抗酸化物質を特定する
主な方法:
- 抗酸化物質と低酸素妊娠の結果に関する臨床前試験の体系的レビュー
- 胎児の心血管プログラムと脳を節約するメカニズムに対する抗酸化効果の比較分析
- ミトコンドリアを標的とする抗酸化物質,特にMitoQの評価
主要な成果:
- 特定の抗酸化物質は,胎児の低酸素に関連した長期的な心血管リスクを軽減する可能性がある.
- 過剰な抗酸化物質の使用は 急性低酸素に対する胎児の脳を救う重要な反応を 損なう可能性があります
- MitoQは,前臨床モデルでは,胎児の脳を保存しながら,プログラムされた心血管疾患から保護する効果を示した.
結論:
- 抗酸化物質は,胎児の低酸素症の心臓血管後遺症を予防するための潜在的な治療戦略です.
- 胎児の適応反応を危うくしないためには 抗酸化物質を慎重に選択することが重要です
- MitoQは,保護効果と保存効果の両方があるため,臨床試験の有望な候補である.
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