関連する実験動画

Updated: Sep 10, 2025

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C
11:53

An Alternative Culture Method to Maintain Genomic Hypomethylation of Mouse Embryonic Stem Cells Using MEK Inhibitor PD0325901 and Vitamin C

Published on: June 1, 2018

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GRK2はDNMT1媒介DNAメチル化再プログラムによるVSMC現象変調をオーケストラする

Chao-Hua Kong1, Yue Sun1, Li-da Wu1

  • 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, China (C.-h.K., Y.S., L.-d.W., W.-y.Z., D.-c.W., Z.-h.J., X.-m.J., P.Y., Y.G., Y.-l.C., S.-l.C.).

Arteriosclerosis, thrombosis, and vascular biology
|August 21, 2025
PubMed
まとめ

Gタンパク質結合受容体キナーゼ2 (GRK2) は血管滑らかな筋肉細胞 (VSMC) の運命を表遺伝的に調節する. GRK2-DNMT1経路をターゲットにすることで,血管再構成疾患に対する新しい治療法を提供することができる.

キーワード:
サイトカインハイパープラジアメチルトランスフェラーゼミオカルディンフェノタイプ

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Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
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