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Updated: Sep 10, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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MAVSのリン酸化は,抗ウイルス免疫を調節する細胞ストレスセンサとして作用する

Dongyi Zhao1,2, Nao Morimoto1, Riho Saito1,2

  • 1Laboratory of Molecular Cell Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.

iScience
|August 21, 2025
PubMed
まとめ

細胞のストレスは,RIG-I型受容体のシグナル伝達における重要なステップであるMAVSのリン酸化を促進することによって,抗ウイルス免疫を強化する. これはストレス経路と I型インターフェロンの産生を結びつけ,ウイルス感染に対する先天的な免疫反応を高めます.

キーワード:
生物化学細胞生物学免疫反応

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