2つの異なる方法によって計算された測定不確実性の結果と,エタノール試験の総分析誤差の評価
Mehmet Akif Bozdayi1, İsmet Gamze Bozdayı2, Gökhan Çakırca1
1Mehmet Akif Inan Education and Research Hospital, Department of Medical Biochemistry, Sanliurfa, Türkiye.
Journal of medical biochemistry
|August 21, 2025
まとめ
測定不確実性 (MU) と総分析誤差 (TAE) は,信頼性の高いエタノール試験に不可欠です. この研究では,MUとTAEを計算し,許容される誤差の範囲内で値を見つけ,法的値の正確な解釈を確保しました.
科学分野:
- 分析化学
- 法医学
- 研究室医療
背景:
- エタノール試験の分析性能指標は,法的意味合いのために不可欠です.
- 測定不確実性 (MU) と分析誤差 (TAE) は,測定品質を評価するための重要な指標です.
- 信頼性の高いエタノール試験結果は 正確な解釈と法的な遵守に不可欠です
研究 の 目的:
- エタノール試験の MU と TAE の値を計算する.
- 異なる視点からエタノール試験結果の信頼性を評価する.
- 2つの異なる計算方法を用いて,法的な値に対する MU 値の影響を評価する.
主な方法:
- MU値は,NordtestとISO/TS 20914のガイドラインに従って計算されました.
- TAEは,TAE%=1. 65×CV%+Bias%という式を用いて決定した.
- 2022年7月から2024年6月までの外部と内部の品質データを使用した.
主要な成果:
- 拡張されたMU値は13. 95% (Nordtest) と10. 94% (低レベル) /9. 59% (高レベル) であった (ISO/ TS 20914).
- 計算されたTAE値は12. 59 (低),11. 47 (高),12. 57 (全体) でした.
- すべての MU と TAE 値は,CLIA 2024 の許容総誤差 ±20% の範囲に留まっていました.
結論:
- 研究室は,エタノール試験の結果を,特に法定値に近い MU値とともに報告すべきである.
- 科学委員会によるMU計算方法の標準化が推奨される.
- 一貫性と信頼性を高めるために,MUの目標値の定義が提案されています.
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