ビタミンD欠乏症と四肢骨折
Emily M Pilc1, Amy Y Zhao2, Sanjay Kubsad3
1Eastern Virginia Medical School at Old Dominion University, 825 Fairfax Ave, Norfolk, VA, 23507, USA.
Journal of clinical orthopaedics and trauma
|August 21, 2025
まとめ
ビタミンD欠乏症は,整体 (THA) または膝 (TKA) 関節整形手術の後の手術後の近義肢骨折 (PPF) のリスクを増加させなかった. この研究では,ビタミンD濃度とPPF発生率または再検査リスクとの間には関連性がないことが判明しました.
科学分野:
- 整形 術
- 栄養学
- 流行病学について
背景:
- 術後の周義肢骨折 (PPF) は,全 (THA) と膝 (TKA) の関節整形手術後の重大な合併症である.
- ビタミンD欠乏症は,PPFに関連した骨粗鬆症の潜在的な危険因子です.
- 以前の推定では,PPFを患っている患者でビタミンD欠乏症の有病率が高いことが示唆されていた.
研究 の 目的:
- ビタミンD欠乏症患者のTHAまたはTKA後10年以内にPPFの累積的な発生率とリスクを調査する.
- ビタミンD状態とPPFの発生との関連を評価する.
- ビタミンDの欠乏が PPFによる再検査手術の必要性を 影響するかどうかを判断する.
主な方法:
- トリネットX研究ネットワークを用いて遡及的なコホート分析が行われました.
- 2010年1月から2021年4月の間にTHAまたはTKAを投与された患者で,血清カルシジオール濃度と少なくとも2年間の追跡データが見つかりました.
- ビタミンD欠乏症の患者と欠乏症の患者を1対1で比較するために,傾向スコアをマッチングした.
主要な成果:
- 研究には合計15226人の患者が参加した.
- ビタミンD欠乏群のPPFの累積発生率は,対照群のTHA (0. 60% 対 1. 68%) とTKA (0. 26% 対 0. 47%) に比べて低かった.
- ビタミンD欠乏症とTHA (HR: 0. 69) またはTKA (HR: 0. 80) の後のPPFのリスクとの間には統計的に有意な関連性は認められなかった.
結論:
- ビタミンD欠乏症は,整体股関節または膝関節整形手術後の手術後の周関節骨折の発生率またはリスクの増加と関連していません.
- この研究では,PPFによるビタミンD欠乏とリビジョン手術のリスクとの間には相関関係がないことが判明しました.
関連する概念動画
01:25Role of Vitamins in Maintaining Bone Health
3.6K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.6K
01:29Bone Disorders
3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
01:23Role of Skin in Vitamin D Synthesis
5.6K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.6K
01:21Skeleton and Calcium Homeostasis
4.8K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.8K
01:31Essential Minerals for Bone Health
4.4K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.4K
01:22Connective Tissue Cell Types
3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K