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Updated: Sep 10, 2025

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
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口腔状細胞癌に対する高度な薬物投与システム:ナノテクノロジーに基づくその他の革新的なアプローチの包括的なレビュー

Alain Herrada Céspedes1,2,3, Montserrat Reyes4, Javier O Morales1,2,3

  • 1Drug Delivery Laboratory, Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile.

Frontiers in drug delivery
|August 21, 2025
PubMed
まとめ

先進的な薬物投与システム (DDS) は,積極的な口腔がん (OSCC) の治療に有望である. ナノテクノロジーとAIを用いたこれらの標的治療は 効果を向上させ 副作用を軽減することを目的としていますが 課題は残っています

キーワード:
薬物投与システム免疫療法インテリジェント・ヒドロゲル脂質ナノ粒子ナノテクノロジー口腔がん口腔状細胞がん光力学療法

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
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