薬物治療を受けていない強迫性障害の患者における集団認知行動療法後のネットワーク間およびネットワーク内接続性の低下
Zong-Feng Zhang1,2, Yan He1,2, Yu-Qiu Su1,2
1Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang Province, China.
World journal of psychiatry
|August 21, 2025
まとめ
集団認知行動療法 (GCBT) は,強迫性障害 (OCD) の患者の脳の接続性を改善しました. 主要なネットワークの機能的接続性の低下は,認知機能の強化と相関しており,治療反応の潜在的神経イメージングマーカーを提供している.
科学分野:
- 神経科学
- 精神科
- 認知科学
背景:
- 集団認知行動療法 (GCBT) は,強迫性障害 (OCD) の効果的な治療法です.
- OCD患者におけるGCBT後の脳ネットワーク内および脳ネットワーク間の機能的接続性 (FC) の変化は十分に理解されていません.
研究 の 目的:
- GCBT前と後の非薬用OCD患者における認知関連のネットワークにおける休息状態機能的接続性 (rs-FC) の異常を調査する.
- rs-FCと認知機能の変化を評価することによって,GCBTの治療効果を検証する.
主な方法:
- 休息状態の機能性磁気共鳴画像 (rs- fMRI) は,強迫症患者33人と健康な対照群26人に実施された.
- OCD患者は12週間のGCBT介入前と後に rs-fMRIを受けた.
- FCは,デフォルトモードネットワーク (DMN),背側注意ネットワーク (DAN),突起ネットワーク (SAN),およびフロントパリエタルネットワーク (FPN) の内および間を分析した. 神経心理学的テストは 記憶,実行機能,注意力,視覚空間的能力を評価した.
主要な成果:
- rs- FCの有意な減少は,DMNとDAN内で,そしてGCBT後のDMN- DAN,DMN- FPN,DMN- SAN,およびDAN- SANネットワーク間で観察されました.
- 記憶,実行機能,注意力,視覚空間能力などの認知機能は,治療後の有意な改善を示した.
- DMN rs- FCの減少は,実行機能と視覚空間能力の改善と相関する. 他のネットワークの変化は 特定の認知テストのパフォーマンスと相関しています
結論:
- GCBTは,OCD患者のネットワーク間およびネットワーク内 rs- FCに重大な変化をもたらします.
- DMNとDAN内の rs-FCの低下は,特に執行機能と相関すると,OCDにおけるGCBT応答を予測する神経画像バイオマーカーとして機能する.
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