非規制された関節炎サプリメントの有害効果と患者の認識:セーフティネットのプライマリケアクリニックでの遡及的混合方法研究
Vi D Nguyen1, Elizabeth M Canales2, Kenneth Pettersen2
1Department of Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Cureus
|August 21, 2025
まとめ
デキサメトゾンのような隠された薬剤を 知らないまま 処方箋外で販売される関節炎サプリメントを使用した患者は 痛みの軽減だけでなく 副腎機能不全を含む 副作用も経験しました 医師 の 勧め に よっ て 服用 を 中止 し た 人 も 多い.
科学分野:
- 薬理学について
- 公衆衛生
- 患者の安全
背景:
- 慢性痛の治療には 補足療法や代替療法が一般的です
- 処方箋外 (OTC) の関節炎サプリメントは,しばしば自然なものとして宣伝されますが,未開示の処方薬が含まれています.
- 隠された薬剤成分は,臨床的な監視なしに,健康に重大なリスクをもたらします.
研究 の 目的:
- OTC 関節炎サプリメントの使用に関する患者の経験,認識,動機を調査する.
- FDAの警告と潜在的な害にもかかわらず 患者がこれらのサプリメントを使用する理由を理解するために
- 隠された成分と関連するリスクに対する患者の認識を評価する.
主な方法:
- 臨床医は,FDAが警告したOTC関節炎サプリメントを使用している患者を特定しました.
- 半構造的な電話インタビューで 患者の報告データを評価した.
- 臨床データとコルチゾールのレベルは,有害事象のために分析されました.
主要な成果:
- 薬剤 (デキサメタゾン,ディクロフェナック,メトカルバモール) を含んだアルトリ・キングのようなサプリメントを使用したと報告した患者は12人でした.
- 動機付けには,推奨,処方された治療からの弱い救済,および自然な安全感が含まれています.
- 患者の3/5は痛みを和らげましたが,腎上腺機能不全を含む副作用が報告されました.
結論:
- 慢性疼痛の患者は,安全性や従来の治療の不十分さから OTCサプリメントを使用し,隠された医薬品のリスクを認識していません.
- 副腎機能不全や心血管疾患など,深刻な有害事象を引き起こします.
- 臨床医はサプリメントの使用をチェックし 患者をリスクについて教育し より安全な痛み管理戦略を促進しなければなりません
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