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Updated: Sep 10, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

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薬物-ポリマーの溶解性および混合性の経験的およびハイブリッドモデリングを通じて無形固体分散を進める:イブプロフェンを用いたケース研究

Matheus de Castro1, Ana Sara Cordeiro1, Mingzhong Li1

  • 1Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, United Kingdom.

International journal of pharmaceutics: X
|August 21, 2025
PubMed
まとめ

この研究では,モデリングとDSCを用いて,4つのポリマーでイブプロフェンの溶解性を評価した. KOL17PFは最高の互換性を示し,HPMCASは薬物の負荷が高くても無形固体分散 (ASD) の安定性が限られていた.

キーワード:
アモルフな固体分散 (ASD)ガラスの移行融点沈殿 (MPD)混乱連鎖統計関連流体理論 (PC-SAFT)段階図

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