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Updated: May 6, 2026

Measuring RAN Peptide Toxicity in C. elegans
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病原性の値でのポリグルタミンリピートの発現は,Tauの神経毒性とCのタンパク質蓄積をわずかに増加させる. エレガンス

Joshua C Hincks1, Jade G Stair1, Nicole F Liachko1,2

  • 1Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, United States.

microPublication biology
|August 21, 2025
PubMed
まとめ

ハンチントン病 (HD) は,有毒なポリグルタミン (polyQ) タンパク質を含む. C. elegansでpolyQとtauを同時に発現すると,運動欠陥が悪化し,特にボーダーライン繰り返しの長さでは,tauの病理がHDの進行に影響する可能性があることを示唆しています.

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