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カナダのブリティッシュ・コロンビア州で,最も高価な慢性疾患の治療に伴うCOVID-19 パンデミックの影響:人口ベースのタイムシリーズ分析
Nevena Rebić1,2, Eric C Sayre3, Michael R Law4,5
1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Patient preference and adherence
|August 21, 2025
PubMed で要約を見る
まとめ
COVID-19 パンデミックは,ブリティッシュ・コロンビアのほとんどの慢性疾患の薬の投与順序を大きく変化させなかった. しかし,すべての薬剤群で最適な値を下回る傾向があるため,薬剤の遵守は依然として課題です.
科学分野:
- 医療サービス研究
- 流行病学
- 薬学経済学
背景:
- COVID-19 パンデミック中の処方薬の遵守に関する人口レベルのデータは限られています.
- 高価な慢性疾患の治療に伴う パンデミックの影響を理解することは,医療計画において極めて重要です.
研究 の 目的:
- ブリティッシュ・コロンビアの高コストの慢性疾患の薬剤クラスに対するCOVID-19のパンデミックの影響を評価する.
- パンデミック緩和対策の前と後の順守傾向の変化を分析する.
主な方法:
- ブリティッシュ・コロンビア (BC) で配布されているすべての医薬品の健康管理データを利用した.
- 月間投与日数の割合 (PDC) を用いて定量化した投与順守.
- パンデミック前後のPDC傾向の変化を評価するために,中断されたタイムシリーズ分析 (ITS) を採用した.
主要な成果:
- 26の慢性疾患の薬剤グループで3,906,377人の成人を含む.
- 特に親腸内免疫抑制剤,注射性インスリン,レニン・アニオテンシン系薬剤で,PDC傾向の有意な変化が観察されました.
- 一般的に処方される薬には,抗うつ薬,呼吸道阻害性疾患薬,レニン・アニオテンシン系薬,利尿薬,脂質調節剤が含まれています.
割り切れた時系列分析
結論:
- COVID-19 パンデミックは,一般的に処方される慢性疾患の薬の遵守に大きく影響しませんでした.
- パンデミックに関連した変化に関係なく,研究されたすべての薬剤群において,薬剤の遵守は最適以下であった.
- 医療従事者の服薬の順守は 主要なシステム全体に及ぶストレスの時でさえも 持続的で重要な課題です