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Updated: Sep 10, 2025

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Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
348
遠隔体重管理プログラムにおけるセマグルチドとティルゼパチド:プログラムコンプリターにおける遡及12ヶ月の結果
Becky Richards1, Will Lunt1, Michael Whitman1
1Second Nature, 483 Green Lanes, London, GB.
JMIR formative research
|August 21, 2025
まとめ
グルカゴン型ペプチド-1受容体アゴニスト (GLP- 1RA) プログラムでは,肥満に対する著しい体重減少が示されています. これらのデジタル介入は 伝統的なケアと比較して 効果的で実行可能で 費用も節約できます
科学分野:
- 肥満 医学
- デジタルヘルスの介入
- 薬学的な体重管理
背景:
- 肥満は世界で8億9千万人以上に 影響しており 伝統的な治療法では 長期的に失敗することが多いのです
- グルカゴン類ペプチド-1受容体アゴニスト (GLP- 1RAs) は著しい体重減少を示していますが,専門家のアクセスにはコストと能力が制限されています.
研究 の 目的:
- 12ヶ月のGLP-1RAによるリモート体重管理プログラムの有効性,可行性,受容性,および費用対効果を評価する.
- このリモートプログラム内のティルゼパチドとセマグルチドの結果を比較します.
主な方法:
- ティルゼパチドまたはセマグルチドを用いた12ヶ月のリモート体重管理プログラムで339人の参加者を遡及的に分析した.
- 併用薬,アプリによるサポート,栄養士の指導, 段階的な行動変化のテクニックによる臨床監督のプログラムです
- 主要の結果: 体重の平均変化と体重減少の≥10%および≥15%の達成; 二次の結果: 行動の変化,副作用,可受け入れ性,可行性,費用対効果.
主要な成果:
- 12ヶ月の平均体重減少はティルゼパチドで -22. 9kg,セマグルチドで -18. 1kgでした (P<0. 05).
- ≥10%の体重減少が95. 2% (ティルゼパチド) と83. 1% (セマグルチド) で達成され,≥15%がそれぞれ83. 7%と56. 2%で達成されました.
- 非活動性および初期副作用 (吐き気,疲労,便秘) の有意な減少が観察され,副作用の報告が増加しました.
結論:
- リモートで提供されるGLP-1RAプログラムは,臨床試験に匹敵する体重減少を達成し,従来の英国サービスと比較して大幅なコスト削減 (10-70%) を提供します.
- ティルゼパチドとセマグルチドは,臨床的に有意な体重減少と良好な安全性,そして積極的な行動変化を示した.
- デジタル・デリバリー・モデルは 資源の限られたシステムで 肥満治療へのアクセスを拡大する上で 実現可能で効果的です
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