関連する実験動画

Updated: Sep 10, 2025

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
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Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers

Published on: September 29, 2017

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中枢神経系におけるミトコンドリア移転とホメオスタシスの役割

Anna Gervasi1, Simona D'Aprile1, Simona Denaro1

  • 1Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

Journal of cellular physiology
|August 21, 2025
PubMed
まとめ

コネキシン43 (Cx43) タンパク質は,中枢神経系 (CNS) の細胞伝達とミトコンドリア機能に不可欠です. ミトコンドリアの移転と機能におけるその役割は,神経学的障害に対する潜在的な治療目標を提供します.

キーワード:
ギャップ・ジャンクションホメオスタシス細胞間通信メタボリズム神経学的障害

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Protein Transport into the Inner Mitochondrial Membrane

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Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
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The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
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