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Updated: Sep 10, 2025

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
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HERTACsは,HER2トラフィキングによる膜および細胞外タンパク質の腫瘍選択的リンソーム分解を可能にします

Shipeng He1, Wenjing Huang1, Yaojin Zhu1

  • 1Institute of Translational Medicine, Shanghai University, 99 Shangda Road, Shanghai, 200444, P.R. China.

Angewandte Chemie (International ed. in English)
|August 21, 2025
PubMed
まとめ

新しい標的型タンパク質分解 (TPD) プラットフォームを 開発しました HerTACsと呼ばれるもので 細胞外および膜タンパク質を分解します このアプローチは強力な抗腫瘍活性を示し,精密腫瘍学のための薬剤可能なタンパク質を拡張します.

キーワード:
細胞外および膜タンパク質人間の表皮成長因子受容体2リソソーム標的キメラ標的型タンパク質の分解

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