関連する実験動画

Updated: Sep 10, 2025

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
09:35

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

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MKLN1依存のGID4/CTLH E3ユビキチンリガゼ複合体は,B細胞抗体多様化をサポートするために必要である

Philip Barbulescu1, Matthew K Wong1, Leon Baronian1

  • 1Department of Immunology, University of Toronto, Toronto, ON, Canada.

Journal of immunology (Baltimore, Md. : 1950)
|August 21, 2025
PubMed
まとめ

LisH (CTLH) -MKLN1 E3ユビキチンリガゼ複合体は,抗体多様化に不可欠である. その欠如は, uracil- DNA glycosylase 2 (UNG2) のレベルを増加させることで,B細胞の発達と humoral 免疫を損なう.

キーワード:
B セルC端末からLISHへUNG2 についてクラス・スイッチの再組み合わせソマティック・ハイパーミューテーション

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