主要治療における高血圧患者の治療: STOP- トライアル
PubMedで要約を見る
まとめ
この要約は機械生成です。抗高血圧療法 (AHT) を中止することは,低用量治療を受けた患者の約3分の1が正常な血圧に達した場合に可能である. AHT離脱を成功させるには,120mmHg未満の家庭用血圧モニタリングが重要です.
科学分野
- 心臓病科
- 高血圧管理
- 臨床試験
背景
- 抗高血圧療法 (AHT) は通常終身であり,治療の中止に関する研究は限られている.
- 選択された患者でAHTの停止の可能性を評価することは,パーソナライズされた医療にとって極めて重要です.
研究 の 目的
- モノセラピーまたは低用量ダブルセラピーの患者でAHTの中止の可能性を評価する.
- AHT終了後1年間,正常な血圧 (BP) を維持する予測要因を特定する.
主な方法
- AHTを中止した203人の参加者を対象とした,多中心のオープン・ラベル研究です.
- 主要エンドポイント: 家庭用血圧測定 (HBPM) を用いて1年間正常血圧 (< 135/85 mmHg) を維持する.
- AHT 離脱後の BP 制御の成功と失敗に関連する要因の調査.
主要な成果
- 参加者の36%は,AHTなしで1年間正常血圧 (<135/85 mmHg) を維持した.
- 標準血圧の成功率は60%で,≥120mmHgの成功率は23%でした.
- オフィスの高血圧とホワイトコートの高血圧は,長期的な血圧制御を予測しなかった.
結論
- モノセラピーまたは低用量ダブルAHTを受けている患者の約3分の1は,血圧をコントロールしながら治療を成功裏に中止することができます.
- 発症時の静脈動脈血圧が120mmHg未満の個体では,厳密なモニタリングでAHTの離脱を考慮することができる.
- AHTを中止してから最初の1年間は,血圧の厳密なモニタリングが不可欠です.
関連する概念動画
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