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Updated: Sep 10, 2025

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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LbCas12aの安定性情勢を理解するには,安定化変異と変異組合せを徹底的に分析する必要があります

Jiajun Dong1,2, Shaojie Wang1, Wenxue Xu1

  • 1Shanghai Institute for Advanced Immunochemical Studies and School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China.

Protein science : a publication of the Protein Society
|August 21, 2025
PubMed
まとめ

エンジニアリングされたCas12aの変異は,安定化変異の複雑な相互作用を示し,タンパク質の適性と温度安定性に影響を与えます. これらのエピスタシス効果を理解することは,ゲノム編集と診断のための高度なCas核酸の開発に役立ちます.

キーワード:
LbCas12a についてタンパク質工学安定したエピスタシス

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