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Updated: Sep 10, 2025

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
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FADDDEDフィラメントは,TNF誘発のアポトーシス中に複合IIa集合を調整する

Ying Chen1, Vinh Thang Huynh1, Lihua Lai1

  • 1Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673, Singapore.

Proceedings of the National Academy of Sciences of the United States of America
|August 21, 2025
PubMed
まとめ

この研究では,FADD死亡エフェクタドメイン (DED) のフィラメントは,RIPK1とカスパース-8の採用を促進することによって,外来アポトーシスを開始するために重要であることが明らかになった. このフィラメント形成は,TNF誘発の細胞死亡に不可欠であり,cFLIPに関する新しい洞察を明らかにします.

キーワード:
FADDRIPK1 についてTNFR1 について外部アポトーシスフィラメント

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