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Updated: Sep 10, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

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DNMT1媒介のSPINT2発現は,ヒトの線維芽細胞におけるc-Metシグナル伝達を抑制することによって,早期老化を誘発する

Min Seok Sim1,2, Hae-Ok Byun1,3, Seongki Min1,2

  • 1Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon 16499, Korea.

Aging
|August 21, 2025
PubMed
まとめ

DNAメチルトランスフェラーゼ1 (DNMT1) のダウンレギュレーションは,セリンプロテアゼ阻害剤クニッツ2型 (SPINT2) の発現を増加させ,早期の細胞老化を誘発し,老化および関連疾患に関する新しい洞察を提供します.

キーワード:
DNAメチルトランスファーゼ1 (DNMT1)老化する細胞の老化衰えることセリンプロテアース阻害剤クニッツ2型 (SPINT2)

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Techniques to Induce and Quantify Cellular Senescence06:51

Techniques to Induce and Quantify Cellular Senescence

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

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Replicative Cell Senescence

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