歯周病および関連する全身疾患に対する革新的な治療法としての歯周病阻害剤:体系的なレビュー

Maria Elisa Pedrosa¹, Victor Martin^1,2, Maria Helena Fernandes^1,2

¹Bonelab, Faculdade de Medicina Dentária, Universidade do Porto, Rua Dr. Manuel Pereira da Silva, Porto, 4200-393, Portugal.

Clinical oral investigations

|August 21, 2025

まとめ

炎症と組織損傷を軽減することによって,歯周病 (PD) および関連する全身疾患の治療に期待されています. ヒトでの有効性を確認するには,さらなる臨床試験が必要である.

科学分野:

歯周病学
微生物学
薬理学について

背景:

歯周病 (PD) は,全身疾患に関連する慢性炎症性疾患である.
Porphyromonas gingivalisのプロテアゼであるジンギパインは,PDの病原性における重要なウイルス性因子である.
ガンジパインを抑制することは潜在的な治療戦略です

研究の目的:

ガンジパイン阻害剤のPDおよび関連する全身疾患の管理の可能性を体系的に検討する.
歯痛抑制剤の有効性に関する臨床前および臨床的証拠を評価する.

主な方法:

PubMed,Scopus,Web of Scienceで体系的な文献検索を行いました
PICOSの枠組み (人口,介入,比較,結果,研究設計) に基づいて選択された研究.
研究目標,モデル,阻害剤タイプ,結果の評価

主要な成果:

7 件の臨床試験前試験が含有基準を満たしたが,臨床試験は認められなかった.
臨床前モデルでは,ジンギパイン阻害剤がPDの炎症,細菌負荷,組織破壊を減少させることが示された.
阻害剤は心臓血管疾患とアルツハイマー病のモデルでも改善しました
RgpとKgp酵素を標的にする二重抑制剤は,単一標的にする薬よりも有効でした.

結論:

ジンギパイン阻害剤は,PDおよび関連する全身疾患の治療の可能性を示しています.
臨床試験がないため,さらなる研究と臨床評価が必要である.
これらの阻害剤は,ウイルス性因子を調節し,疾患の進行を緩和する補助療法として機能する.

キーワード:

ポルフィロモナス・ジンギヴァリスアルツハイマー病動脈硬化症ジンギパイン阻害剤歯周病リウマチ性関節炎

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