Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.1K
Phylogenetic Trees03:21

Phylogenetic Trees

46.4K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
46.4K
Phylogeny01:23

Phylogeny

47.1K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
47.1K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.4K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.4K
The Tree of Life - Bacteria, Archaea, Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, Eukaryotes

33.7K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
33.7K
Protein Families02:47

Protein Families

15.7K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
15.7K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Structome-TM: complementing dataset assembly for structural phylogenetics by addressing size-based biases.

Bioinformatics advances·2026
Same author

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.

Nature communications·2026
Same author

Structome-AlignViewer: On Confidence Assessment in Structure-Aware Alignments.

Genome biology and evolution·2026
Same author

Mechanistic and evolutionary insights into a family of aminoacyl-tRNA deacylases that protects against canavanine toxicity.

Nucleic acids research·2025
Same author

Evolution and structural diversity of the MotAB stator: insights into the origins of bacterial flagellar motility.

mBio·2025
Same author

Reduced Amino Acid Substitution Matrices Find Traces of Ancient Coding Alphabets in Modern Day Proteins.

Molecular biology and evolution·2025

関連する実験動画

Updated: Sep 10, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.0K

タンパク質の構造遺伝学

Caroline Puente-Lelievre1,2, Ashar Malik3,4,5, Jordan Douglas2,6

  • 1School of Biological Sciences, The University of Auckland, Auckland, New Zealand.

Genome biology and evolution
|August 21, 2025
PubMed
まとめ
この要約は機械生成です。

タンパク質構造系遺伝学は3D構造を用いて進化史を追跡し,特に低シーケンス類似領域におけるタンパク質進化の洞察を提供している. 人工知能の進歩により 構造データにアクセスしやすくなり 遺伝学的な分析が進んでいます

キーワード:
進化生物学について分子進化遺伝学タンパク質構造レビュー構造的な遺伝学

さらに関連する動画

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.5K
Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
07:49

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

7.1K

関連する実験動画

Last Updated: Sep 10, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.0K
A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.5K
Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
07:49

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group

Published on: August 16, 2017

7.1K

科学分野:

  • 分子進化
  • 構造生物学
  • バイオ情報学

背景:

  • タンパク質の構造は配列よりも保存されていて,進化論の分析に価値があります.
  • その
  • 夕暮れ地帯
  • 低シーケンスの類似性は,従来の系統遺伝的方法に課題を投げかけています.
  • 限られた高解像度構造データは歴史的にフィールドを制限しました.

研究 の 目的:

  • タンパク質の構造遺伝学の現状を見直す
  • 構造データから進化の洞察を抽出する方法を概説する.
  • この分野における重要な応用と将来の方向性を強調する.

主な方法:

  • 3Dタンパク質構造データを用いて 系統遺伝分析を行う.
  • アクセシブルで高品質な構造データのための人工知能の進歩を活用する.
  • タンパク質構造から系統樹を構成する方法を開発し,適用する.

主要な成果:

  • タンパク質の構造的な系統遺伝学は,特に低類似性の挑戦的な領域では,単一の配列よりも大きな進化的解像度を提供します.
  • 人工知能による構造データのアクセシビリティは 過去の制約を克服します
  • 現在の方法は進歩していますが 配列ベースの確率モデルにはまだ遅れがあります

結論:

  • タンパク質の構造遺伝学は急速に進歩する分野であり,大きな可能性を秘めています.
  • 配列と構造データの統合は,系統学的分析を強化する準備ができています.
  • 将来の方向には,確率モデルと学際的な協力のさらなる開発が含まれています.