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Updated: Sep 10, 2025

Purification of Pathogen Vacuoles from Legionella-infected Phagocytes
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LYVAC/PDZD8はライソームの真空化器である

Haoxiang Yang1, Jinrui Xun1, Yajuan Li2

  • 1Aging Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Science (New York, N.Y.)
|August 21, 2025
PubMed
まとめ

リソソームの真空化という一般的な状態は,ERを固定したタンパク質であるPDZD8 (LYVACと改名) によって媒介される. LYVACは脂質を検知し ERからリソソームへの転移と オスモスの膨張を促し 重要な真空化メカニズムを明らかにします

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