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Updated: Sep 10, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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負荷とロック:マクロ分子解離に影響を与える新興の治療法

Raymond J Deshaies1, Patrick Ryan Potts1

  • 1Amgen Research, Thousand Oaks, CA, USA.

Science (New York, N.Y.)
|August 21, 2025
PubMed
まとめ

このレビューでは,解離率 (k_off) を低減することによってマクロ分子複合体を安定させる新薬クラスLOCKTACを紹介しています. このアプローチは タンパク質の相互作用を調節することで 病気に挑戦するための 新しい治療戦略を提供します

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