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Updated: Sep 10, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

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Published on: January 31, 2025

652

肝臓のCYP4A自相性溶解体分解:自相性受容体SQSTM1/ p62が,珍しい標的の相互作用部位を通して重要な役割を果たす

Liang He1, Doyoung Kwon1, Michael J Trnka2

  • 1Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, California.

Molecular pharmacology
|August 21, 2025
PubMed
まとめ

肝臓P450酵素CYP4A11とCyp4a12aは,p62を含むER- リソソーム経路によって分解される. この分解を妨害すると,これらの酵素が安定し,炎症代謝物質の生成が増加し,肝疾患に関連した集積物が形成されます.

キーワード:
オートファージ性溶解体分解 (ALD)化学クロスリンク マススペクトロメトリー (XLMS)サイトクロームP450ER-リソーム関連分解 (ERLAD)エンドプラズマ網膜 (ER) 関連分解 (ERAD)シーケストソーム1 (SQSTM-1/p62)

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