多発性硬化症の患者における上肢と下肢の機能の違い
Heather M DelMastro1, Laura B Simaitis2, Ashley Constantine2
1Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, 490 Blue Hills Ave., Hartford, CT, United States; Department of Rehabilitation Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University, 370 Bassett Road, North Haven, CT, USA.
Multiple sclerosis and related disorders
|August 21, 2025
まとめ
血管関連疾患は多発性硬化症 (MS) の患者の機能,特に歩行と上肢の調整を悪化させる. 糖尿病は MS (PwMS) の人の歩行速度と移動能力に大きく影響します.
科学分野:
- 神経学
- 血管医学
- リハビリテーション科学
背景:
- 多発性硬化症 (PwMS) の患者は,一般人よりも血管関連疾患がより一般的です.
- PwMSにおける肢体の機能に対する血管疾患の影響に関する研究は限られている.
研究 の 目的:
- 血管性併発症と併発症のないPwMSにおける上肢 (UL) と下肢 (LL) の機能を比較する.
- ULまたはLL機能障害に関連する特定の併発症を特定する.
主な方法:
- 横断的な研究の二次分析
- 評価されたLL機能 (25フィートのタイムウォーク,タイムアップとゴー) とUL機能 (指と鼻のテスト,ナインホールペグテスト,グリップ強さ,ボックスとブロックテスト).
- データを分析するために二変数統計と調整された線形回帰を用いた.
主要な成果:
- 血管共同疾患のPwMSは,機能的パフォーマンスを低下させました.
- 血管共同疾患は,コバリアート調整後の歩行速度 (T25FW),移動能力 (TUG),UL調整 (FNT) の劣化と相関する.
- 糖尿病はT25FWとTUGのパフォーマンスの低下と有意に関連していました.
結論:
- 血管疾患は,歩行,バランス,運動能力,UL調整におけるMSに関連する機能的欠陥を悪化させる.
- 糖尿病は歩行や移動能力の低下の重要な要因です.
- 血管疾患と多発性硬化症の組み合わせを強調し 個別的なケアプランを策定しました
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