関連する実験動画

Updated: Sep 10, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
11:45

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles

Published on: August 22, 2018

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強力なSHP2アロステリック阻害剤の新型アザビサイクルシリーズ

Alessio Sferrazza1, Ilaria Rossetti1, Danilo Fabbrini1

  • 1Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy.

Bioorganic & medicinal chemistry letters
|August 21, 2025
PubMed
まとめ

研究者はがんの成長を標的とする新しいアロステリックSHP2阻害剤を開発しました. これらの強力な化合物は細胞測定で有望であり,さらなる有効性評価のために動物実験に進む可能性があります.

キーワード:
アロステリック阻害アザビサイクロ[4.1.0]ヘプタン腫瘍学リン酸塩SHP2 についてpERK について

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