早期発症の炎症性腸疾患の手術による治療

Sarah J Ullrich¹, Annie Le-Nguyen¹, Monica Holder¹

¹Colorectal Center at Cincinnati Children's Hospital, Division of Pediatric General & Thoracic Surgery, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

Journal of pediatric surgery

|August 21, 2025

まとめ

早期発症の炎症性腸疾患 (VEO- IBD) の患者の22%は手術が必要である. 黒人人種,早期診断,疾患の重症度などの要因が VEO-IBD の手術の必要性に影響します.

科学分野:

小児胃腸内科
小児外科
炎症性腸疾患の研究

背景:

早期発症性炎症性腸疾患 (VEO-IBD) の発生率は6歳未満の子どもで増加しています.
VEO- IBDは独特の臨床的特徴,治療への反応,およびアウトカムを示しています.
VEO-IBDにおける外科的介入の役割は,まだ十分に理解されていません.

研究の目的:

VEO- IBDと診断された小児患者の外科的治療戦略と結果を調べる.
この集団における手術の必要性に関連する要因を特定する.

主な方法:

一つの施設で2008年1月から2024年5月にかけて診断された121人のVEO-IBD患者の遡及的レビュー.
収集されたデータには,人口統計,臨床的特徴,および疾患の重症度が含まれています.
記述的統計はデータ分析に使用された.

主要な成果:

クローン病は最も一般的な表型 (61. 2%) で,しばしば大腸 (62. 8%) に影響した.
手術は21. 5%の患者で必要で,オストミーの形成と腸切除は一般的な手術である.
黒人人種,1歳未満の診断,身長速度の低下,近腸疾患,および疾患の重症度が手術介入と有意に関連していました.

結論:

この調査は単一センターでの最大の調査で VEO-IBDにおける手術の割合は22%でした
手術の必要性に影響を与える主な要因には,黒人人種,診断時の年齢,疾患の重症度,身長速度の低下,および近部疾患が含まれます.
異質なVEO-IBD症例の管理における手術の役割と結果を明らかにするために,さらなる研究が不可欠です.

キーワード:

小児結腸外科小児炎症性腸疾患早期発症する炎症性腸疾患

さらに関連する動画

08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

15.1K

04:05

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment

Published on: May 31, 2024

475

関連する概念動画

01:21

Inflammatory Bowel Disease V: Surgical Management

212

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

212

01:29

Inflammatory Bowel Disease IV: Pharmacological Management

189

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

189

01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

419

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

419

01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

202

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...

202

01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

267

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...

267

01:17

Chronic Bowel Disorders: Introduction

540

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

540

関連する実験動画