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Updated: Sep 10, 2025

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
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Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

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ターゲット媒介薬剤配置モデルを用いた抗CD47抗体のモデルによる最適な投与量

Seongmee Jeong1, Sung Young Lee2, Sung Ho Kim2

  • 1College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.

Clinical and translational science
|August 21, 2025
PubMed
まとめ

新しい抗体IMC- 002は,CD47を標的とし,がん細胞のファゴシトーシスを強化します. 薬理学モデルから,将来の臨床試験のために3週間ごとに20 mg/ kgの最適な投与レジメンが示されました.

キーワード:
アンチCD47抗体モデルによる最適な用量ターゲットメディエイトド・ドラッグ・ディポジション・モデル (TMDD)

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