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エプスタイン バール ウイルス は 世界 的 に 乳がん の 危険 に 寄与 し て いる か 体系的なレビューとメタ分析
Francisco Cezar Aquino de Moraes1, Pedro Henrique de Souza Wagner2, Ana Beatriz Nardelli da Silva1
1Federal University of Pará, Belém, Pará, Brazil.
Clinical breast cancer
|August 21, 2025
PubMed で要約を見る
まとめ
エプスタイン・バーウイルス (EBV) は,世界的に乳がん (BC) 組織の25%に存在します. このメタ解析は,特に低所得地域とトリプルネガティブサブタイプで,EBVの存在と乳がんのリスクの増加との間に有意な関連性があることを示唆しています.
科学分野:
- 腫瘍学
- ウイルス学
- 流行病学について
背景:
- 乳がん (BC) は,世界の女性における主要な癌です.
- エプスタイン・バーウイルス (EBV) は,腫瘍性ウイルスとして知られています.
- 新興の証拠は,BCの病原性におけるEBVの潜在的な役割を示唆しています.
研究 の 目的:
- 乳がん組織におけるEBVの世界的流行を調査する.
- EBVと乳がんのリスクとの関連性を評価する.
- 異なる大陸,所得層,BCサブタイプにおける EBV 流行の変動を調査する.
主な方法:
- 5,133個のBC組織を含む57の研究のランダム効果メタ解析を行った.
- 95%信頼区間 (CI) を用いて推定された原始比率とリスク比率 (RR)
- 大陸,所得レベル,BCサブタイプによるサブグループ分析を行いました.
主要な成果:
- 全球EBV感染率はBC組織で25% (95%CI:21% - 30%) であった.
- コントロールと比較して,BC組織におけるEBVのリスクが著しく高かった (RR: 3.35,P < .001).
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