Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.6K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.6K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

9.5K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
9.5K
Olfaction01:25

Olfaction

45.1K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
45.1K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.

Translational psychiatry·2026
Same author

New neurons flatten social hierarchies.

Scientific reports·2026
Same author

Multidomain correlates of burnout: A population-based study using supervised machine learning.

Social psychiatry and psychiatric epidemiology·2026
Same author

How personality functioning shapes symptom development during and after treatment: A random intercept cross lagged panel analysis.

Comprehensive psychiatry·2026
Same author

"Locked in my body, caught up in my mind": Neural signatures of body image rumination in anorexia nervosa.

Brain research bulletin·2026
Same author

Menarche onset is an inflection point for mental health and brain development.

bioRxiv : the preprint server for biology·2026
Same journal

Microbiota-gut-brain axis in autism spectrum disorder: integrating brain structure, function, and transcriptomics.

Translational psychiatry·2026
Same journal

Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.

Translational psychiatry·2026
Same journal

Maraviroc attenuates inflammation-exacerbated cognitive and amyloid pathology in an early-stage Alzheimer's disease mouse model.

Translational psychiatry·2026
Same journal

High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?

Translational psychiatry·2026
Same journal

Immune-metabolic mediation of depression risk: Causal evidence from antibody and metabolite GWAS.

Translational psychiatry·2026
Same journal

DRD1 and DRD2 dopamine-sensitive neurons in the central amygdala respond differently to rewarding and aversive stimuli.

Translational psychiatry·2026
関連記事をすべて見る

関連する実験動画

Updated: Sep 10, 2025

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research
06:13

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Published on: January 19, 2024

1.1K

嗅覚神経の刺激を通して,突起ネットワークの接続性を調節する.

Carina Heller1,2,3,4,5,6, Maria Geisler7, Nicolas L Mayer8

  • 1Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. carina.heller@uni-jena.de.

Translational psychiatry
|August 21, 2025
PubMed
まとめ
この要約は機械生成です。

嗅覚粘膜の電気刺激は 脳の接続性を変えて うつ病を助長するかもしれません この新しいアプローチは 突出ネットワークとデフォルトモードネットワークを ターゲットにしており 将来の治療法に 期待を寄せています

さらに関連する動画

A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.7K
A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
10:42

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

Published on: August 18, 2014

9.1K

関連する実験動画

Last Updated: Sep 10, 2025

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research
06:13

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Published on: January 19, 2024

1.1K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.7K
A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
10:42

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

Published on: August 18, 2014

9.1K

科学分野:

  • 神経科学
  • 精神科
  • 脳の接続性

背景:

  • 鬱病は脳のサリアンスネットワーク (SN) とデフォルトモードネットワーク (DMN) の機能的接続性の変化と関連しています
  • うつ病では 神経パターンを修正することは 臨床的に困難です
  • 嗅覚経路はSNへの直接的な経路を提供し,標的神経調節の可能性を示唆しています.

研究 の 目的:

  • 嗅覚神経の刺激が脳に与える影響を 研究するために
  • 嗅覚刺激がサリエンスネットワークとデフォルトモードネットワークとの相互作用を調節できるかどうかを調べる.

主な方法:

  • ランダム化され,盲目化され,被験者内のデザインが使用されました.
  • 45人の健康な被験者は嗅覚神経または三生神経刺激を受けた.
  • 休息状態の機能的磁気共鳴画像 (fMRI) を用いて脳の接続性を評価した.

主要な成果:

  • 嗅覚刺激は,神経回路と皮質皮質 (嗅覚領域) の間の機能的接続性を有意に増加させた.
  • この刺激により,SN内の接続性が強化されました.
  • 嗅覚刺激によって SNとDMNの接続性が弱まった.

結論:

  • 嗅覚刺激は,うつ病に関連する脳の接続パターンを調節する可能性があることを示しています.
  • これは気分障害に対する 新しく最小侵襲的な 治療戦略を示唆しています
  • うつ病と診断された個体での有効性を確認するには,さらなる研究が必要である.