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関連する概念動画

Signal Transduction: Overview01:26

Signal Transduction: Overview

9.3K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
9.3K
Ligand Binding Sites02:40

Ligand Binding Sites

13.2K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
13.2K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

4.9K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
4.9K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
Overview of Cell Signaling01:23

Overview of Cell Signaling

21.2K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
21.2K
Internal Receptors01:31

Internal Receptors

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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
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下流遺伝子の機能的サポートによる空間的に変動するリガンド受容体相互作用の発見

Shiying Li1, Ruohan Wang1, Sitong Liu1

  • 1Department of Computer Science, City University of Hong Kong, Hong Kong, China.

Nature communications
|August 21, 2025
PubMed
まとめ

SPIDERは空間的変数のリガンド受容体相互作用 (LRIs) を空間的トランスクリプトミクスを使用して識別します. この方法は 細胞間のコミュニケーションパターンと 複雑な組織における生物学的意義を 正確に明らかにします

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Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
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Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis

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Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay
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Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay

Published on: March 3, 2011

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関連する実験動画

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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

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Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
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Detection of Signaling Effector-Complexes Downstream of BMP4 Using in situ PLA, a Proximity Ligation Assay
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科学分野:

  • ゲノミクス
  • コンピュータ生物学
  • システム生物学

背景:

  • 空間トランスクリプトミクスは,空間的な文脈で細胞間リガンド受容体相互作用 (LRIs) を研究することを可能にします.
  • 空間的に変化するLRIを特定することは,組織組織と機能を理解するために不可欠です.

研究 の 目的:

  • スパイダー (SPIDER) は,空間的に変数のLRIを活性化証拠で特定するための新しい計算フレームワークです.
  • 空間的に変化する相互作用 (SVI) 信号をプロファイルし,識別する方法を開発する.

主な方法:

  • SPIDERは,細胞の相互作用能力に基づいて,細胞間の相互作用インターフェースを構築します.
  • 下流転写因子によってサポートされるSVI信号を識別するために複数の確率モデルを使用します.
  • この方法は,シミュレーションと実際のデータセットを使用して,大量および単細胞解像度で検証されます.

主要な成果:

  • SPIDERは,既存の方法と比較して,より高い精度,特異性,および空間的差異を示しています.
  • 検証されたSVIは,生物学的複製物における下流の標的遺伝子との空間的自己相関と相関を示している.
  • ネズミのデータセットの異なるSVIは,地域的および細胞間型の相互作用を強調しています.

結論:

  • SPIDERは空間的に変化するリガンド受容体相互作用を効果的に識別し,特徴づけます.
  • フレームワークはSVIをパターンに分類し,細胞型領域内の相互作用ベースのサブクラスターと強化された経路を明らかにします.