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Updated: Sep 10, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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LYMTACs:キメリック小分子は,標的タンパク質の移転と分解のためにリゾソーム膜タンパク質を再利用する

Dhanusha A Nalawansha1, Georgios Mazis2, Gitte Husemoen2

  • 1Induced Proximity Platform, Amgen Research, Thousand Oaks, CA, USA. dnalawan@amgen.com.

Nature communications
|August 21, 2025
PubMed
まとめ

研究者らは新しい小分子プラットフォームである LYソーム膜ターゲティングキメラ (LYMTAC) を開発した. LYMTACsはリンソーム分解のための膜タンパク質を標的とし,がんを誘発する遺伝子を制御する新しい方法を提供します.

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