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Updated: Sep 10, 2025

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
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METTL16によるU6 snRNA m6Aの構造とメカニズム

Jue Ju1, Kozo Tomita2

  • 1Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo Kashiwa, Chiba, Japan.

Nature communications
|August 21, 2025
PubMed
まとめ

METTL16酵素はU6 snRNAをメチル化し,これは正確なmRNA前スプライシングのための重要なステップです. 構造研究は,METTL16が効率的なN6-メチラデノシン改変のためにU6 snRNAを募集し,再配置する方法を示しています.

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