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タバリ・コホートにおける未診断の慢性腎疾患の流行:集団ベースの研究
Mahmood Moosazadeh1, Farhad Gholami2, Pedram Ebrahimnejad3
1Gastrointestinal Cancer Research Center, Non-Communicable Diseases Research Institute, Mazandaran University of Medical Sciences, Mazandaran, Iran.
BMC nephrology
|August 21, 2025
まとめ
大規模な集団研究では,診断されていない第3段階の慢性腎疾患 (CKD) の高い罹患率が認められた. 都市部に住む人々や高血圧,糖尿病,心血管疾患のない人々は 診断されていないCKDを患う可能性が高くなりました
科学分野:
- 腎臓科
- エピデミオロジー
- 公衆衛生
背景:
- 慢性腎臓病 (CKD) は 世界的な健康問題です
- 初期段階のCKDはしばしば症状がないので 診断が遅れる.
- 診断されていないCKDの調査は公衆衛生の介入に不可欠です.
研究 の 目的:
- 大規模な集団における未診断の3段階CKDの罹患率を決定する.
- 診断されていない第3段階のCKDに関連する要因を特定する.
主な方法:
- タバリコホート研究 (TCS) のデータ (2015年-2017年) の横断分析
- 35歳から70歳までの成人の10255人を含む.
- MDRD方程式を用いて推定された球過濾率 (eGFR) に基づくCKDの診断;ステージ3のCKDは30 ≤eGFR <60mL/min/1.73m2と定義される.
- 予測要因を特定するためのロジスティック回帰分析
主要な成果:
- 参加者の25. 6%がCKD第3段階でした.
- ステージ3のCKD患者の98. 1%は自分の状態を知らなかった.
- 診断されていない第3段階のCKDのリスクは,山岳地帯の住民や高血圧,糖尿病,心血管疾患の患者で低かった.
結論:
- 人口の大部分は3段階のCKDと診断されていません.
- 都市部での居住と併発性疾患 (高血圧,糖尿病,心血管疾患) の欠如は,診断されていない第3段階のCKDのより高い罹患率と関連しています.
- 対象となるスクリーニングと啓発プログラムの必要性を強調しています.
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