周回的に投与された23. 4%の塩化ナトリウムの安全性
Christian R Silva1, Jessica Nagy2, Andrew R Zullo2,3
1Rhode Island Hospital, Brown University Health, Providence, RI, USA. Csilva15@brownhealth.org.
Neurocritical care
|August 21, 2025
まとめ
23. 4% の塩化ナトリウムを外側から投与することは,頭蓋内圧上昇の治療に安全です. 糖尿病のリスクが増加するにもかかわらず,この高血圧療法では,患者にとって重大な損傷のない低血流率を示した.
科学分野:
- クリティカル ケア 医療
- 緊急 医療
- 腎臓科
背景:
- 23. 4% の塩化ナトリウムによる高酸素治療は,頭蓋内圧上昇の管理に極めて重要です.
- 中枢静脈カテーテル設置は治療を遅らせ,患者の結果を悪化させる可能性があります.
- 周周静脈注射 (IV) は,潜在的により迅速な代替手段である.
研究 の 目的:
- 23. 4% の塩化ナトリウムを周回性IVカテーテルで投与する安全性と有効性を評価する.
- エクストラバゼーションと関連する患者の怪我の発生率を評価する.
主な方法:
- 2つの病院の場所での遡及観察コホート研究
- 周縁のIV経由で23. 4%の塩化ナトリウムを投与した成人患者も含まれていた.
- 投与後24時間以内に死亡または退院した患者は除外した.
主要な成果:
- 863回の投与で低濃度 (6. 4%) が観察されました.
- 組織死滅や外科手術の症例は報告されていません.
- 糖尿病はリスク因子として特定され,エクストラバゼーションのリスクを2. 39倍に増加させた.
結論:
- 23. 4% の塩化ナトリウムを周周回的にIV投与することは,傷害のリスクが最小限である安全な選択肢です.
- 糖尿病患者の早期発見は,エクストラバゼーションのリスクを軽減するために重要です.
関連する概念動画
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
304
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
304
01:19Depolarizing Blockers: Pharmocokinetics
379
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
379
01:12Local Anesthetics: Adverse Effects
492
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
492
01:24Hemodialysis II: Procedure and Complications
129
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
129
01:25Hemodialysis III: Nursing Management
183
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
183
01:25Routes of Drug Administration: Parenteral
2.1K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
2.1K