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Updated: Sep 10, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

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Published on: April 12, 2019

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低酸素誘発のM2マクロファージから派生したオステオポントンは,EGR3/ISG15シグナル伝達とRIG-I発現の調節によって骨肉腫の進行を促進する

Chunyang Xing1, Wei Hu2, Liyuan Zhao3

  • 1Department of Orthopedics, School of Medicine, First Affiliated Hospital of Zhejiang University, Qingchun Road No.79, Hangzhou, 310002, Zhejiang, China. xing@zju.edu.cn.

Journal of translational medicine
|August 22, 2025
PubMed
まとめ

低毒性M2マクロファージは,EGR3とISG15を抑制し,RIG- Iを上昇させ,オステオポントン (OPN) による骨肉腫の進行を促進する. この研究では 骨癌の発症の 重要なメカニズムが明らかになりました

キーワード:
EGR3 について低酸素症ISG15 についてM2 マクロファージオステオポントンオステオサルコマRIG-I

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