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Updated: Sep 10, 2025

Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells
09:51

Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells

Published on: June 30, 2023

1.0K

ガン治療における新しい時代:プロテアソーム-Bcl-2軸を標的とする

Sourabh Soni1, Vandana Anang1, Yutong Zhao1,2

  • 1Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Journal of experimental & clinical cancer research : CR
|August 22, 2025
PubMed
まとめ

Dysregulated B細胞リンパ腫-2 (Bcl-2) タンパク質は癌に影響する. Ubiquitin-proteasome system (UPS) は,Bcl-2のレベルを制御し,治療目標を提供している. このレビューは,がんの進行と治療におけるプロテアソーム-Bcl-2軸を調査しています.

キーワード:
アポトーシスBcl-2ファミリータンパク質癌についてプロテアソーム阻害剤治療的可能性ウビキチン-プロテアソームシステム (UPS)ウビキチネーション

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