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Updated: Sep 10, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

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変異性AR-LBDにおけるリガンド誘発型変化の暴露:アンドロゲン受容体-共活性化メカニズムに関する分子動態の洞察

Madiha Sardar1, Nadeem Ahmad1, Mamona Mushtaq2

  • 1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Journal of chemical information and modeling
|August 22, 2025
PubMed
まとめ

アンドロゲン受容体 (AR) 変異は,ARを対抗状態から対抗状態に変化させ,前立腺がん治療の有効性を低下させることがあります. この研究は,AR-LBD変異がコアクティベーターの相互作用をどのように変化させ,このシフトを促し,新しい治療標的を提供することを明らかにしています.

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