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RAGEターゲットを介して老化疾患の調節:食事介入のレビュー

Qian Wu¹, Jia Yan¹, Yuyan Zhang¹

¹Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei, 430068, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|August 22, 2025

まとめ

高度な糖分化最終産物 (RAGE) の受容体を標的とする戦略は,老化に関連する病気と闘う上で極めて重要です. RAGEの調節に安全で予防的なアプローチを提案しています

科学分野:

ゲロントロジー
分子生物学
栄養学

背景:

世界の人口の老化は老化に関連した病気の管理のための効果的な戦略を必要とします.
高度な糖分化最終産物 (RAGE) の受容体は,糖尿病やアルツハイマー病などの慢性疾患に関与しています.
リガンドによるRAGEの活性化により,炎症とストレス経路 (NF-κB,MAPK) が誘発され,治療対象となる.

研究の目的:

RAGE-リガンドの相互作用と下流のシグナリングを体系的に検討する.
RAGE調節のための標的型介入戦略を探求する.
RAGE経路による抗老化における食事中の生物活性化合物の役割を強調する.

主な方法:

RAGEシグナル伝達経路に関する文献レビュー
RAGE-リガンドの相互作用の分析
RAGE調節剤としての食事中の生物活性化合物 (ポリフェノール,ポリサカリド,テルペノイド) の試験

主要な成果:

RAGEは老化に関連した疾患の病原化に中心的な役割を果たします.
RAGEの活性を調節する可能性がある.
機能的な食品は老化を予防する戦略に利点があります

結論:

RAGEを食事療法でターゲットにすると栄養による予防の理論的根拠となる.
ダイエットのアプローチは WHOの"老化を予防する"というコンセプトと一致しています
アンチエイジングの栄養予防へのパラダイムシフトが支持されています.

キーワード:

RAGE について老化による病気ダイエット相互作用モジュレーション

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