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Updated: Sep 10, 2025

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
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Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

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プロテオミックプロファイリングは,結腸直腸がんの進行の原動力としてストロマルTGF-β1/ポドプラニン軸を特定する

Silvia Di Agostino1, Davide La Padula2, Vittoria Rago3

  • 1Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, 88100, Italy. sdiagostino@unicz.it.

Journal of experimental & clinical cancer research : CR
|August 22, 2025
PubMed
まとめ

ポドプラニン (PDPN) は結腸直腸がん (CRC) で高濃度で,腫瘍の増殖を促進し,ストロマ細胞のサポートを強化し,潜在的な治療標的となる. 高PDPN発現は患者の生存率の低下と相関しており,予後値を示しています.

キーワード:
癌に関連する線維芽細胞大腸がんプロテオミック変形成長因子β腫瘍に関連するマクロファージ腫瘍の微小環境YAP/TAZ

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