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Dentate GyrusのミトファジーとグリアにO-GlcNAcylationの上昇の影響

Joshua Kramer1, Sarah Fu1, Xiaosen Ouyang1

  • 1Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Journal of neurochemistry
|August 22, 2025
PubMed
まとめ

O-GlcNAcylationの上昇は,星球細胞のミトファギーを阻害し,脳内の膠質ホメオスタシスを変化させます. このタンパク質の改変はミトコンドリアの品質管理に影響を与え,神経変性疾患の発生に影響を与える可能性があります.

キーワード:
O-GlcNAcアストロサイトヒポカンプスマイクログリアミトファジー

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