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Updated: Sep 10, 2025

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
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Published on: January 22, 2019

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p400複合体は,ウイルスの転写を抑制し,宿主細胞の状態を変更することによって,HIV-1の潜伏期を促進します

Luisa P Mori1,2, Chuan Li2, Thomas Venables2

  • 1The Skaggs Graduate School of Chemical and Biological Sciences, The Scripps Research Institute, Jupiter, FL, 33458, United States.

Nucleic acids research
|August 22, 2025
PubMed
まとめ

EP400を含むp400複合体は,RNAポリメラーゼIIの延長を制限することによって,ヒト免疫不全ウイルス1型 (HIV-1) の転写を阻害する. EP400を枯渇させると 休眠状態のHIV-1が再活性化され ウイルスの根絶戦略の標的となるのです

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